Gene information
Official symbol PTGIS
Official full name prostaglandin I2 synthase
Gene type protein-coding gene
Chromosome20q13.13
Alias symbolPGIS; CYP8A1
Gene familyCytochrome P450 family 8
Resources
Entrez Gene 5740
HGNC HGNC:9603
Ensembl ENSG00000124212
Vega OTTHUMG00000033077
UCSC uc002xut.4
GO terms: 68 records
GO Description Category LogP Number of genes Detail
GO:0001516 prostaglandin biosynthetic process GO Biological Processes -6.90547690 6 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001676 long-chain fatty acid metabolic process GO Biological Processes -13.6883394 17 More
GO:0004497 monooxygenase activity GO Molecular Functions -11.8172125 15 More
GO:0005506 iron ion binding GO Molecular Functions -10.4063739 16 More
GO:0005901 caveola GO Cellular Components -18.8033423 19 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006633 fatty acid biosynthetic process GO Biological Processes -12.0711739 16 More
GO:0006636 unsaturated fatty acid biosynthetic process GO Biological Processes -5.20458879 6 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006692 prostanoid metabolic process GO Biological Processes -9.18831190 9 More
GO:0006693 prostaglandin metabolic process GO Biological Processes -9.18831190 9 More
GO:0006753 nucleoside phosphate metabolic process GO Biological Processes -1.97459133 12 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009117 nucleotide metabolic process GO Biological Processes -2.02959005 12 More
GO:0009165 nucleotide biosynthetic process GO Biological Processes -1.85527211 8 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO Molecular Functions -11.3284001 18 More
GO:0016829 lyase activity GO Molecular Functions -1.51492560 6 More
GO:0016835 carbon-oxygen lyase activity GO Molecular Functions -1.83729949 4 More
GO:0016836 hydro-lyase activity GO Molecular Functions -1.39258351 3 More
GO:0016853 isomerase activity GO Molecular Functions -1.41249432 5 More
GO:0016860 intramolecular oxidoreductase activity GO Molecular Functions -2.53594783 4 More
GO:0019369 arachidonic acid metabolic process GO Biological Processes -15.7454969 15 More
GO:0020037 heme binding GO Molecular Functions -15.4577568 20 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0032088 negative regulation of NF-kappaB transcription factor activity GO Biological Processes -5.01152693 15 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033559 unsaturated fatty acid metabolic process GO Biological Processes -16.8056258 19 More
GO:0034654 nucleobase-containing compound biosynthetic process GO Biological Processes -2.18989332 18 More
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway GO Biological Processes -4.70690316 6 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0036294 cellular response to decreased oxygen levels GO Biological Processes -14.5279047 32 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043433 negative regulation of DNA-binding transcription factor activity GO Biological Processes -10.6964949 32 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045019 negative regulation of nitric oxide biosynthetic process GO Biological Processes -5.51502780 7 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045428 regulation of nitric oxide biosynthetic process GO Biological Processes -19.2075726 26 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046456 icosanoid biosynthetic process GO Biological Processes -13.7551761 13 More
GO:0046457 prostanoid biosynthetic process GO Biological Processes -6.90547690 6 More
GO:0046906 tetrapyrrole binding GO Molecular Functions -14.8570803 20 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0055086 nucleobase-containing small molecule metabolic process GO Biological Processes -1.91021091 13 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0071453 cellular response to oxygen levels GO Biological Processes -14.8173809 34 More
GO:0071456 cellular response to hypoxia GO Biological Processes -14.4449186 31 More
GO:0072330 monocarboxylic acid biosynthetic process GO Biological Processes -12.0346130 18 More
GO:0080164 regulation of nitric oxide metabolic process GO Biological Processes -19.7892071 27 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity GO Molecular Functions -4.25319477 3 More
GO:0120254 olefinic compound metabolic process GO Biological Processes -12.8805599 18 More
GO:1901293 nucleoside phosphate biosynthetic process GO Biological Processes -1.83737953 8 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904406 negative regulation of nitric oxide metabolic process GO Biological Processes -5.51502780 7 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa00590 Arachidonic acid metabolism KEGG Pathway -11.1782370 12 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
phenylbutazone inhibitor TdgClinicalTrialTEND 3517382643494039175451713928417016423 view
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
NP_000952.1:p.Glu461Ala genomics myocardial infarction[diagnosis] myocardial infarction Xie X et al. Zhonghua Yu Fang Yi Xue Za Zhi. 2009
NC_000019.10:g.[8311547G>A;49505441A>G;49510639T>C;49517245G>A;49524145C>G;49536138A>G;48177784G>A] genomics myocardial infarction[diagnosis] myocardial infarction Lemaitre RN et al. Atherosclerosis. 2009
NM_000961.4:c.[*2479T>C;1117C>A;252C>T] genomics myocardial infarction[diagnosis] myocardial infarction Xiang X et al. Clin Appl Thromb Hemost. 2009
NM_000961.4:c.[*2479T>C;1117C>A;252C>T] genomics myocardial infarction[diagnosis] myocardial infarction Ma YT et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2009
NM_000961.4:c.1117C>A genomics myocardial infarction[diagnosis] myocardial infarction Nakayama T et al. Am Heart J. 2002
NM_000961.4:c.1117C>A genomics myocardial infarction[diagnosis] myocardial infarction Xie X et al. Zhonghua Liu Xing Bing Xue Za Zhi. 2008
NM_000961.4:c.1117C>A genomics myocardial infarction[diagnosis] myocardial infarction Xie X et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
NM_000961.4:c.1117C>A genomics myocardial infarction[diagnosis] myocardial infarction Ma YT et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2009
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